XDH ELISA Kit for Human(Homo sapiens) | EIAab.comXDH ELISA Kit for Human(Homo sapiens)

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Index > Protein center > XDH(Gene name) > Human

XDH (Gene name),

Xanthine dehydrogenase/oxidase (Protein name ), XDH_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

XDH(XDHA);

Protein name:

Xanthine dehydrogenase/oxidase;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with BTN1A1.

Function:

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).

Subcellular Location:

Cytoplasm Peroxisome Secreted

Protein Attributes:

Sequence length:

1333

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

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1050:

1100:

1150:

1200:

1250:

1300:

1333:

ATPEKIRNAC | VDKFTTLCVT | GVPENCKPWS | VRV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P47989

KEGG:

hsa:7498

Pfam:

PF01315

STRING:

9606.ENSP00000368727

MIM:

278300

UniGene:

Hs.250

String:

P47989

Uniprot:

P47989

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ELISA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

E0760b

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96T

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ELISA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

E0760h

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96T

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ELISA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

E0760r

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96T

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ELISA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

E0760m

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96T

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ELISA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

E0760c

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Packing:

96T

CLIA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

U0760m

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MSDS:

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Packing:

96T

CLIA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

U0760r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

U0760h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

U0760b

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Xanthine dehydrogenase/oxidase

Cat.:

U0760c

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Packing:

96T

Polyclonal Antibody for Human Xanthine dehydrogenase/oxidase

Cat.:

P0760Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Xanthine dehydrogenase/oxidase

Cat.:

P0760Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Xanthine dehydrogenase/oxidase

Cat.:

P0760Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Xanthine dehydrogenase/oxidase

Protein for Human Xanthine dehydrogenase/oxidase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene."
Ichida K. , Amaya Y. , Noda K. , Minoshima S. , Hosoya T. , Sakai O. , Shimizu N. , Nishino T.
Gene133:279-284(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

Ichida K.
Submitted (2000-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 191; 231 AND 1150
3.

"Molecular cloning, tissue expression of human xanthine dehydrogenase."
Xu P. , Huecksteadt T.P. , Harrison R. , Hoidal J.R.
Biochem. Biophys. Res. Commun.199:998-1004(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-172
tissue: Liver.
4.

Xu P. , Huecksteadt T.P. , Harrison R. , Hoidal J.R.
Biochem. Biophys. Res. Commun.215:429-429(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
5.

"Cloning and expression in vitro of human xanthine dehydrogenase/oxidase."
Saksela M. , Raivio K.O.
Biochem. J.315:235-239(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY
tissue: Small intestine.
6.

NIEHS SNPs program
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-133; ARG-172; MET-235; MET-395; SER-555; ALA-584; GLN-607; ASN-617; ILE-623; VAL-646; VAL-703; MET-910; LEU-1091; THR-1109; CYS-1176 AND TRP-1296
7.

"Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria."
Ichida K. , Amaya Y. , Kamatani N. , Nishino T. , Hosoya T. , Sakai O.
J. Clin. Invest.99:2391-2397(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN XU1;VARIANT ARG-1150
8.

"XDH gene mutation is the underlying cause of classical xanthinuria: a second report."
Levartovsky D. , Lagziel A. , Sperling O. , Liberman U. , Yaron M. , Hosoya T. , Ichida K. , Peretz H.
Kidney Int.57:2215-2220(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN XU1
9.

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074
tissue: Milk.
10.

"Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate."
Yamaguchi Y. , Matsumura T. , Ichida K. , Okamoto K. , Nishino T.
J. Biochem.141:513-524(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF MUTANT VAL-803 IN COMPLEX WITH FAD; 2FE-2S IRON-SULFUR CENTERS; SALICYLATE; MOLYBDOPTERIN AND CALCIUM IONS;COFACTOR;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT
11.

"Human milk xanthine dehydrogenase is incompletely converted to the oxidase form in the absence of proteolysis. A structural explanation."
Pearson A.R. , Godber B.L.J. , Eisenthal R. , Taylor G.L. , Harrison R.
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.59 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR CENTERS;TISSUE SPECIFICITY;ENZYME REGULATION;DISULFIDE BONDS
12.

"Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria."
Sakamoto N. , Yamamoto T. , Moriwaki Y. , Teranishi T. , Toyoda M. , Onishi Y. , Kuroda S. , Sakaguchi K. , Fujisawa T. , Maeda M. , Hada T.
Hum. Genet.108:279-283(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XU1 CYS-149
13.

"Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria."
Gok F. , Ichida K. , Topaloglu R.
Nephrol. Dial. Transplant.18:2278-2283(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN XU1
14.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-763 AND GLY-791

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